Antiviral coffee

日期:2017-04-16 05:36:52 作者:司城蜀 阅读:

AN EXTRACT from green coffee beans may inspire the next generation of anti-HIV drugs. Edward Robinson, a molecular pathologist at the University of California at Irvine, reported in 1996 that chicoric acid from coffee beans can stop the HIV from replicating in cell cultures. But his suggestion that the compound blocked the enzyme integrase, which inserts HIV into human chromosomes, was controversial. “There was a lot of scepticism,” he says, “because there were no drugs that could block integrase.” This month Robinson and Peter King report in the Journal of Virology (vol 72, p 8420) that a single amino acid change in integrase renders HIV resistant to chicoric acid, which proves that integrase is its target. Although chicoric acid is too weak to work in humans,