Cancer researchers strike gold

日期:2017-06-19 01:52:17 作者:周钕雾 阅读:

By Lila Guterman in Florence COMPOUNDS made from gold and silver may make good anticancer drugs, say researchers in Australia and New Zealand. The unpleasant side effects of chemotherapy often come from the drugs’ inability to selectively attack cancer cells. Recent research suggests that drugs may be able to kill cancer cells by targeting their energy-producing mitochondria, which have more highly charged membranes than those in normal cells. To develop positively charged drugs that could cross the mitochondrial membrane, Susan Berners-Price and her team at Griffith University in Brisbane, Australia, with Mark McKeage of the University of Auckland in New Zealand, turned to gold and silver. They found that in mice, these compounds could kill ovarian cancer cells that were resistant to a common cancer drug called cisplatin that has no charge and targets DNA. The researchers speculate that the positive charge on the new molecules helps them to penetrate the mitochondria and thus disrupt the cells’ source of energy. By slightly altering an organic part of the molecule, Berners-Price says she can change both the selectivity of the compounds and their potency against cancer cells. “There are lots of things you can do to fine-tune the activity of the compounds,