Highs and lows

日期:2017-05-26 05:55:46 作者:狄堰 阅读:

By Alison Motluk THE power of psychoactive drugs may vary during the female menstrual cycle, researchers in Italy have found. Although women consume more than two thirds of drugs prescribed for depression and anxiety, almost all drugs are tested only on men and male animals. Paola Palanza and Laura Gioiosa at the University of Parma gave female mice two types of anti-anxiety drugs, each of which affects different neurotransmitters. Benzodiazepines increase the inhibitory effect of gamma-aminobutyric acid (GABA), while buspirone binds to serotonin receptors. Mice in oestrus needed only a small dose of buspirone. During other parts of the cycle, however, the mice needed five times as much buspirone to calm them, the researchers told a meeting on animal behaviour in Urbino, Italy, last week. The animals were also more sensitive to benzodiazepines during oestrus. “In a lot of scientific fields, females have been neglected as subjects,” says Palanza,