Double whammy

日期:2017-09-21 03:31:24 作者:狄堰 阅读:

THE anti-inflammatory drug ibuprofen turns out to have an unexpected—and unwanted—effect in people with cystic fibrosis. The drug has been used to reduce inflammation in the lungs of people with the hereditary disease, but it does not always work well. Now scientists have found out why. People with CF make a faulty version of the protein that normally acts as a channel to shuttle chloride ions in lung tissue. The fault stops the protein doing its job, causing the lungs of people with CF to become clogged with mucus. Daniel Devor and Bruce Schultz of the University of Pittsburgh in Pennsylvania have discovered that ibuprofen can clog the same channel (The Journal of Clinical Investigation, vol 102,